Publications

• Miton CM,  Buda K and Tokuriki N, Current opinion in structural biology 2021 
• Copp JN, Pletzer D, Brown AS, Van der Heijden J, Miton CM, Edgar RJ , … “Mechanistic understanding enables the rational design of salicylanilide combination therapies for Gram-negative infections” mBio 11 (5)62020
• Miton CM, Chen JZ , Ost K, Anderson DW, Tokuriki N “Statistical analysis of mutational epistasis to reveal intramolecular interaction networks in proteins” Methods in Enzymology 643, 243-28012020
• Yang G, Miton CM, Tokuriki N “A mechanistic view of enzyme evolution” Protein Science 29 (8), 1724-1747
• Baier F, Hong N, Yang G, Pabis A, Miton CM, Barrozo A, Carr PD, Lamerlin SCL, Jackosn CJ, Tokuriki N*, “Cryptic genetic variation shapes the adaptive evolutionary potential of enzymes” eLife, 2019, 8, e40789
• Miton CM, Jonas S, Fischer G, Duarte F, Mohamed MF, van Loo B, Kintses B, Kamerlin SCL, Tokuriki N, Hyvönen M, Hollfelder F. “Evolutionary repurposing of a sulfatase: A new Michaelis complex leads to efficient transition state charge offset” Proc Natl Acad Sci USA. 2018 Jul 31;115(31) 
•  Miton, C. M., & Tokuriki, N. (2016). How mutational epistasis impairs predictability in protein evolution and design. Protein Science. 25 (7), 1260–1272.
• Colin, P-Y., Kintses, B., Gielen, F., Miton, C. M., Fischer, G., Mohamed, M. F., et al. (2015). Ultrahigh-throughput discovery of promiscuous enzymes by picodroplet functional metagenomics. Nature Communications, 6, 10008.